T CELL RECRUITING POLYPEPTIDES BASED ON TCR ALPHA/BETA REACTIVITY

The present technology provides T cell recruiting polypeptides that specifically bind to the constant domain of a human and of a non-human primate TCR. The present technology also provides nucleic acids, vectors, and compositions. The polypeptides can be used in methods for treatment of cancer. La p...

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Bibliographic Details
Main Authors VERHELST, JUDITH, ROOBROUCK, ANNELIES, VAN HOORICK, DIANE, STAELENS, STEPHANIE, NEYT, KATRIJN, VAN BELLE, TOM
Format Patent
LanguageEnglish
French
Published 23.06.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present technology provides T cell recruiting polypeptides that specifically bind to the constant domain of a human and of a non-human primate TCR. The present technology also provides nucleic acids, vectors, and compositions. The polypeptides can be used in methods for treatment of cancer. La présente invention concerne des polypeptides de recrutement de lymphocytes T qui se lient spécifiquement au domaine constant d'un TCR d'être humain et d'un TCR de primate non humain. La présente technologie concerne également des acides nucléiques, des vecteurs et des compositions. Les polypeptides peuvent être utilisés dans des procédés de traitement du cancer.
Bibliography:Application Number: CA20213203141