PROCESSES FOR THE PREPARATION OF SOLUBLE SALTS OF INOSITOL PHOSPHATES

• Main Authors: ISERN AMENGUAL, BERNAT, MORENO SATURINO, MARCO ANTONIO, PERELLO BESTARD, JOAN
• Format: Patent
• Language: English; French
• Published: 23.06.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides processes for preparing soluble salts of inositol phosphate characterized by a low level of impurities. Processes for preparing soluble salts (e.g., alkali-metal or ammonium) of inositol phosphates (e.g., hexasodium or dodecasodium salts), and of inositol hexaphosphate in particular (e.g., Na6IP6 and Na12IP6), are described. Also provided are pharmaceutical compositions, methods of use, combination treatments, kits, and articles of manufacture comprising soluble salts of inositol phosphates prepared according to the method of the invention. La présente invention concerne des procédés de préparation de sels solubles de phosphate d'inositol caractérisés par un faible taux d'impuretés. L'invention concerne également des procédés de préparation de sels solubles (par exemple, un métal alcalin ou de l'ammonium) de phosphates d'inositol (par exemple, des sels d'hexasodium ou de dodécasodium), et de l'hexaphosphate d'inositol, en particulier (par exemple, Na6IP6 et Na12IP6). L'invention concerne en outre des compositions pharmaceutiques, des procédés d'utilisation, des traitements combinés, des kits et des articles manufacturés comprenant des sels solubles de phosphates d'inositol préparés par le procédé selon l'invention.