MASP INHIBITORY COMPOUNDS AND USES THEREOF

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for...

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Bibliographic Details
Main Authors FLAMME, INGO, XU, JIANCHAO, JUHL, CATHLEEN, ZUBOV, DMITRY, TERSTEEGEN, ADRIAN, NEUBAUER, THOMAS, BAUMANN, LARS, XIONG, JIANCHENG, BIERER, DONALD, DREHER, JAN, HOLTON, SIMON, GLATZ, MARIE
Format Patent
LanguageEnglish
French
Published 12.05.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries. La présente invention concerne de nouveaux composés bicycliques inhibiteurs de la sérine-protéase associée à la lectine liant le mannose (MBL) (MASP), ainsi que des procédés de préparation de ceux-ci, l'utilisation de ceux-ci seuls ou en association pour le traitement et/ou la prévention de maladies et leur utilisation pour la production de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles rénaux et cardiovasculaires et de lésions d'ischémie-reperfusion.
Bibliography:Application Number: CA20213200103