CRYSTALLINE SOLID MEGLUMINE SALT INHIBITOR OF BCL AND METHODS OF MAKING AND USING SAME

• Main Authors: LIAO, LIANG, SHI, ALBERT, GUZ, NATHAN, NING, YUXI, LI, JANE, LU, YUE
• Format: Patent
• Language: English; French
• Published: 19.05.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are the crystalline solid meglumine salts of (R)-5-(4-chlorophenyl)-1-isopropyl-2-methyl-4-(3-(4-(4-((4-((1-(phenylthio)-4-(4- ((phosphonooxy)methyl)piperidin-1-yl)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl) piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid. Pharmaceutical compositions having one or more of the crystalline solid meglumine salt compounds and methods for administering the crystalline solid meglumine salt compounds to a subject are also described. Methods for preparing the crystalline solid meglumine salt compounds are also provided. L'invention concerne des sels de méglumine solides cristallins de l'acide (R)-5-(4-chlorophényl)-1-isopropyl-2-méthyl-4-(3-(4-(4-((4-((1-(phénylthio)-4-(4- ((phosphonooxy)méthyl)pipéridin-1-yl)butan-2-yl)amino)-3-((trifluorométhyl)sulfonyl)phényl)sulfonamido)phényl) pipérazin-1-yl)phényl)-1H-pyrrole-3-carboxylique. L'invention concerne également des compositions pharmaceutiques ayant un ou plusieurs des composés de sel de méglumine solides cristallins et des méthodes d'administration des composés de sel de méglumine solides cristallins à un sujet. L'invention concerne également des procédés de préparation des composés de sel de méglumine solides cristallins.