MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

• Main Authors: HADIDA RUAH, SARA SABINA, ANDERSON, COREY DON, KRENITSKY, PAUL, FANNING, LEV TYLER DEWEY, ISHIHARA, YOSHIHIRO, KHATUYA, HARIPADA, ZHOU, JINGLAN, MCCARTNEY, JASON, ARUMUGAM, VIJAYALAKSMI, SILINA, ALINA, TRAN, JOE A, PARASELLI, PRASUNA, CLEVELAND, THOMAS, VALDEZ, LINO, VICKERS, TROY, FRIEMAN, BRYAN A, ABRAHAM, SUNNY, ABELA, ALEXANDER RUSSELL, GULEVICH, ANTON V, CLEMENS, JEREMY, MELILLO, VITO, DWIGHT, TIMOTHY A, CHAU, JACLYN, GROOTENHUIS, PETER, UY, JOHNNY, PIERRE, FABRICE, COON, TIMOTHY RICHARD, MILLER, MARK THOMAS
• Format: Patent
• Language: English; French
• Published: 14.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators. La présente invention concerne des modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique (RTFK) ayant une structure de coeur (I), des compositions pharmaceutiques contenant au moins un tel modulateur, des procédés de traitement de maladies médiées par le RTFK, y compris la fibrose kystique, à l'aide de tels modulateurs et de telles compositions pharmaceutiques, des compositions pharmaceutiques combinées et des polythérapies utilisant ces modulateurs, ainsi que des procédés et des intermédiaires pour fabriquer de tels modulateurs.