TREATMENT OF NSCLC PATIENTS WITH TUMOR INFILTRATING LYMPHOCYTE THERAPIES

The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an a...

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Bibliographic Details
Main Authors FARDIS, MARIA, FINCKENSTEIN, FRIEDRICH GRAF
Format Patent
LanguageEnglish
French
Published 14.04.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an anti -PD- 1 antibody and/or anti-PD-Ll antibody and/or VEGF inhibitor, or wherein the NSCLC has a predetermined tumor proportion score (TPS). La présente invention concerne des méthodes et des processus améliorés et/ou abrégés pour préparer des TIL afin de préparer des populations thérapeutiques de TIL avec une efficacité thérapeutique accrue pour le traitement du carcinome pulmonaire non à petites cellules (CPNPC), le CPNPCétant réfractaire au traitement avec un anticorps anti-PD-1 et/ou un anticorps anti-PD-Ll et/ou un inhibiteur de VEGF, ou le CPNPC ayant un score de proportion tumorale (TPS) prédéterminé.
Bibliography:Application Number: CA20213195019