COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEREDITARY ANGIOEDEMA

Described herein are compositions and methods for treating a subject having or at risk of developing hereditary angioedema. Using the compositions and methods of the disclosure a patient may be provided one or more agents that elevate the expression and/or activity levels of C1 -esterase inhibitor (...

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Bibliographic Details
Main Authors SAGOO, PERVINDER, MARKS-BLUTH, JONATHON SIMEON, WOLFE, JIA, GASPAR, BOBBY, PENNUCCI, VALENTINA, LEMOINE, ADRIEN
Format Patent
LanguageEnglish
French
Published 17.02.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Described herein are compositions and methods for treating a subject having or at risk of developing hereditary angioedema. Using the compositions and methods of the disclosure a patient may be provided one or more agents that elevate the expression and/or activity levels of C1 -esterase inhibitor (C1-INH). Exemplary agents that may be used in conjunction with the compositions and methods of the disclosure for this purpose include cells, such as pluripotent cells, that express C1- INH. La présente invention concerne des compositions et des méthodes pour traiter un sujet présentant ou risquant de développer un angio-dème héréditaire. Les compositions et les méthodes selon l'invention permettent d'administrer à un patient un ou plusieurs agents destinés à augmenter les niveaux d'expression et/ou d'activité de l'inhibiteur de la C1 estérase (C1-INH). Des exemples d'agents qui peuvent être utilisés conjointement avec les compositions et les méthodes selon l'invention à cet effet comprennent des cellules, telles que des cellules pluripotentes, exprimant le C1-INH.
Bibliography:Application Number: CA20213191729