IMMUNOLOGICALLY COMPATIBLE CELLS, TISSUES, ORGANS, AND METHODS FOR TRANSPLANTATION FOR SILENCING, HUMANIZATION, AND PERSONALIZATION WITH MINIMIZED COLLATERAL GENOMIC DISRUPTIONS

• Main Authors: HOLZER, PAUL W, CHANG, ELIZABETH J, ROGERS, KAITLYN, MONROY, RODNEY L, ADKINS, JON
• Format: Patent
• Language: English; French
• Published: 03.03.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

A biological system for generating and preserving a repository of personalized, humanized transplantable cells, tissues, and organs for transplantation, wherein the biological system is biologically and metabolically active (living), the biological system comprising genetically reprogrammed proteins, cells, tissues, and/or organs in a non-human animal donor for transplantation into a human recipient, wherein the non-human animal donor is a genetically reprogrammed porcine donor for xenotransplantation of cells, tissue, and/or an organ isolated from the genetically reprogrammed porcine donor. La présente invention concerne un système biologique de génération et de conservation d'un centre de stockage de cellules, tissus, et organes transplantables humanisés, personnalisés, pour la transplantation, le système biologique étant biologiquement et métaboliquement actif (vivant), le système biologique comprenant des protéines, cellules, tissus, et/ou organes génétiquement reprogrammés dans un animal donneur non humain pour la transplantation chez un receveur humain, l'animal donneur non humain étant un donneur porcin génétiquement reprogrammé pour la xénotransplantation des cellules, tissu, et/ou d'un organe isolé du donneur porcin génétiquement reprogrammé.