METHODS FOR ENCAPSULATING POLYNUCLEOTIDES INTO REDUCED SIZES OF LIPID NANOPARTICLES AND NOVEL FORMULATION THEREOF

Provided herein are lipid formulations of reduced size, comprising a lipid and a capsid free, non-viral vector (e.g., ceDNA), and methods of producing said lipid formulations. Lipid particles (e.g., lipid nanoparticles) of the disclosure include a lipid formulation that can be used to deliver a caps...

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Bibliographic Details
Main Authors GALLAGHER, NOLAN, STANTON, MATTHEW G, FEINSTEIN, GREGORY
Format Patent
LanguageEnglish
French
Published 20.01.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are lipid formulations of reduced size, comprising a lipid and a capsid free, non-viral vector (e.g., ceDNA), and methods of producing said lipid formulations. Lipid particles (e.g., lipid nanoparticles) of the disclosure include a lipid formulation that can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like). L'invention concerne des formulations lipidiques de taille réduite, comprenant un lipide et un vecteur non viral exempt de capside (par exemple, ceDNA), et des procédés de production desdites formulations lipidiques. Des particules lipidiques (par exemple, des nanoparticules lipidiques) de l'invention comprennent une formulation lipidique qui peut être utilisée pour administrer un vecteur d'ADN non viral exempt de capside à un site cible d'intérêt (par exemple, cellule, tissu, organe et analogues).
Bibliography:Application Number: CA20213186033