ANTI-CLAUDIN 18.2 ANTIBODY AND ANTIBODY-DRUG CONJUGATE THEREOF

Provided are an antibody targeting Claudin 18.2, an antibody-drug conjugate, and use thereof in treatment of cancer. Also provided are a nucleotide encoding the Claudin 18.2 antibody, a polynucleotide combination, an expression vector, an expression vector combination, a pharmaceutical composition c...

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Main Authors LUO, WENTING, SHEN, YUELEI, LI, SHENJUN, WANG, LING, LI, YUANHAO, ZHANG, XIAOPING, JIANG, JING, FANG, JIANMIN, ZHU, MARIE M, YANG, FANG, WANG, LILI, ZHANG, QINBIN
Format Patent
LanguageEnglish
French
Published 17.11.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are an antibody targeting Claudin 18.2, an antibody-drug conjugate, and use thereof in treatment of cancer. Also provided are a nucleotide encoding the Claudin 18.2 antibody, a polynucleotide combination, an expression vector, an expression vector combination, a pharmaceutical composition comprising the Claudin 18.2 antibody and the antibody-drug conjugate, and an application thereof in preparation of a medication for treatment or prevention of cancer. L'invention concerne un anticorps ciblant la claudine 18.2, un conjugué anticorps-médicament, et leur utilisation dans le traitement du cancer. L'invention concerne également un nucléotide codant pour l'anticorps de claudine 18.2, une combinaison de polynucléotides, un vecteur d'expression, une combinaison de vecteurs d'expression, une composition pharmaceutique comprenant l'anticorps de claudine 18.2 et le conjugué anticorps-médicament, et une utilisation correspondante dans la préparation d'un médicament pour le traitement ou la prévention du cancer.
Bibliography:Application Number: CA20223184403