VIRUSES ENGINEERED TO PROMOTE THANOTRANSMISSION AND THEIR USE IN TREATING CANCER

In certain aspects, the disclosure relates to a virus engineered to comprise one or more polynucleotides that promote thanotransmission by a target cell. Thanotransmission is communication between cells that is a result of activation of a cell turnover pathway in a target cell, which signals a respo...

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Bibliographic Details
Main Authors NAGARAJAN, NIRANJANA ADITI, GOUGH, PETER JOSEPH, KAISER, WILLIAM JOSEPH, SCHMIDT, DARBY RYE, DHAKAL, SABIN
Format Patent
LanguageEnglish
French
Published 06.01.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:In certain aspects, the disclosure relates to a virus engineered to comprise one or more polynucleotides that promote thanotransmission by a target cell. Thanotransmission is communication between cells that is a result of activation of a cell turnover pathway in a target cell, which signals a responding cell to undergo a biological response. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are also disclosed. Dans certains aspects, la divulgation concerne un virus modifié pour comprendre un ou plusieurs polynucléotides favorisant la thanotransmission par une cellule cible. La thanatotransmission est une communication entre cellules résultant de l'activation d'une voie de renouvellement cellulaire dans une cellule cible, qui signale à une cellule répondante de produire une réponse biologique. L'invention concerne également des procédés de promotion de la transmission par une cellule cible, des procédés de promotion d'une réponse immunitaire chez un sujet, et des méthodes de traitement du cancer chez un sujet.
Bibliography:Application Number: CA20213184366