SOLID FORMS OF APOL1 INHIBITOR AND USING THE SAME

The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (...

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Main Authors SHRESTHA, MUNA, WITKOS, FAITH, GAGNON, KEVIN JAMES, LI, JICONG, MEDEK, ALES, MINCHOM, JACK RAPHAEL, SHI, YI
Format Patent
LanguageEnglish
French
Published 16.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (I). L'invention concerne de nouvelles formes à l'état solide du composé I choisi parmi la forme solvate d'éthanol A, la forme B de solvate d'éthanol, la forme cristalline A, et la forme B, des compositions les comprenant, et des procédés de fabrication et d'utilisation de celles-ci, comprenant l'utilisation dans le traitement d'une maladie rénale médiée par APOL1. (I).
Bibliography:Application Number: CA20213183591