INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF

Provided herein are compounds of formula (I') or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm, and Rn are as defined elsewhere herein. Also provided herein are methods of prepari...

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Bibliographic Details
Main Authors LEE, PATRICK SANG TAE, MORGANS, DAVID JOHN, MELLEM, KEVIN, SINZ, CHRISTOPHER JOSEPH, POWERS, HANNAH L, WON, WALTER
Format Patent
LanguageEnglish
French
Published 22.09.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are compounds of formula (I') or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm, and Rn are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (F). Also provided herein are methods of inhibiting GYS1 and methods of treating a GYS1 -mediated disease, disorder, or condition in an individual in need thereof. L'invention concerne des composés de formule (I') ou un stéréo-isomère ou un tautomère associé, ou un sel pharmaceutiquement acceptable de l'un quelconque des éléments précédents, dans laquelle Y2, Y3, L1, L2, X1, X2, X3, X4, X5, Q1, R1, R2, Rk, Rm et Rn sont tels que définis ailleurs dans la description. L'invention concerne également des procédés de préparation de composés de formule (F). L'invention concerne également des méthodes d'inhibition de GYS1 et des méthodes de traitement d'une maladie, d'un trouble ou d'un état médié par GYS1 chez un individu qui en a besoin.
Bibliography:Application Number: CA20223179181