PROCESS FOR THE PREPARATION OF A CHIRAL PIPERAZINE-2-CARBOXYLIC ACID

The invention relates to a novel process for the preparation of a chiral piperazine-2- carboxylic acid or of a salt thereof of the formula (I). The chiral piperazine-2-carboxylic acid derivatives of the formula (I) are key intermediates for the preparation of fused heteroaryl dihydro pyrimidines whi...

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Bibliographic Details
Main Authors SPURR, PAUL, PUENTENER, KURT, TOSATTI, PAOLO, FEDOU, NICOLAS MICKAEL, IDING, HANS, STOCKER, PATRICK, HILDBRAND, STEFAN, CINQUALBRE, JOSEPHINE ELIETTE FRANCOISE, WETZL, DENNIS
Format Patent
LanguageEnglish
French
Published 04.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel process for the preparation of a chiral piperazine-2- carboxylic acid or of a salt thereof of the formula (I). The chiral piperazine-2-carboxylic acid derivatives of the formula (I) are key intermediates for the preparation of fused heteroaryl dihydro pyrimidines which are useful for the treatment and prophylaxis of hepatitis B virus infections. La présente invention concerne un nouveau procédé de préparation d'un acide pipérazine-2-carboxylique chiral ou d'un sel de celui-ci de formule (I). Les dérivés d'acide pipérazine-2-carboxylique chiral de formule (I) sont des intermédiaires clés pour la préparation d'hétéroaryl-dihydropyrimidines fusionnées qui sont utiles pour le traitement et la prophylaxie d'infections par le virus de l'hépatite B.
Bibliography:Application Number: CA20213179165