MULTISPECIFIC PROTEINS

The present invention relates to multispecific proteins comprising designed ankyrin repeat domains with binding specificity for different targets, such as, e.g. CD40 and FAR. In addition, the invention relates to nucleic acids encoding such multispecific proteins, pharmaceutical compositions compris...

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Main Authors LEVITSKY, VICTOR, VEITONMAKI, NIINA ELISABET, DOMKE, CLARA, TRAIL SMITH, PAMELA ANNA, CALABRO, VALERIE PERRINE, RIGAMONTI, NICOLO
Format Patent
LanguageEnglish
French
Published 18.11.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to multispecific proteins comprising designed ankyrin repeat domains with binding specificity for different targets, such as, e.g. CD40 and FAR. In addition, the invention relates to nucleic acids encoding such multispecific proteins, pharmaceutical compositions comprising such multispecific proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating or diagnosing diseases, such as cancer, in a mammal, including a human. La présente invention concerne des protéines multispécifiques comprenant des domaines de répétition d'ankyrine conçus ayant une spécificité de liaison pour différentes cibles, telles que, par exemple, CD40 et FAR. De plus, l'invention concerne des acides nucléiques codant pour de telles protéines multispécifiques, des compositions pharmaceutiques comprenant de telles protéines multispécifiques ou des acides nucléiques, et l'utilisation de telles protéines multispécifiques, acides nucléiques ou compositions pharmaceutiques dans des méthodes de traitement ou de diagnostic de maladies, tel que le cancer, chez des mammifères, y compris l'être humain.
Bibliography:Application Number: CA20213178785