HUMANIZED, MOUSE OR CHIMERIC ANTI-CD47 MONOCLONAL ANTIBODIES

Humanized, mouse or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to human glycosylated and deglycosylated CD47 with an optimized Koff value, they disrupt the human CD47-SIRPa interaction, and find use in various therapeutic, preventive or diagnostic methods. The inventi...

Full description

Saved in:
Bibliographic Details
Main Authors CHALONS-COTTAVOZ, MARIE, FALLOT, STEPHANIE, LAHMAR, MEHDI, GARRONE, PIERRE, BELTRAMINELLI, NICOLA, SCHWAMBORN, KLAUS
Format Patent
LanguageEnglish
French
Published 20.07.2017
Online AccessGet full text

Cover

More Information
Summary:Humanized, mouse or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to human glycosylated and deglycosylated CD47 with an optimized Koff value, they disrupt the human CD47-SIRPa interaction, and find use in various therapeutic, preventive or diagnostic methods. The invention includes isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid and nucleotide sequences of the antibodies.
Bibliography:Application Number: CA20173177526