NEW TRIAZINOINDOLE COMPOUNDS

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2, R3a and R3b are defined in the description, and where the compounds may be useful as medicaments, for in...

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Bibliographic Details
Main Authors OEHLRICH, DANIEL, LAMKANFI, MOHAMED, VEGA-RAMIRO, JUAN ANTONIO, VAN OPDENBOSCH, NINA, VAN GOOL, MICHIEL LUC MARIA
Format Patent
LanguageEnglish
French
Published 04.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2, R3a and R3b are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity. La présente invention concerne de nouveaux composés destinés à être utilisés en tant qu'inhibiteurs de la production de l'inflammasome NLRP3, lesdits composés étant tels que définis par les composés de formule (I), et les nombres entiers R1, R2, R3a et R3b étant définis dans la description, et où les composés peuvent être utiles en tant que médicaments, par exemple pour une utilisation dans le traitement d'une maladie ou d'un trouble qui est associé à l'activité de l'inflammasome NLRP3.
Bibliography:Application Number: CA20213176688