BINDING PROTEINS USEFUL AGAINST ACE2-TARGETED VIRUSES

Described herein are binding proteins useful against ACE2-targeted viruses (e.g., SARS-CoV and SARS-CoV-2, etc.), and methods of using them. These binding proteins may include an extracellular portion of angiotensin-converting enzyme 2 (ACE2), excluding the collectrin domain, and a flexible polypept...

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Bibliographic Details
Main Authors TIRUTHANI, KARTHIK, CRUZ TERAN, CARLOS ALBERTO, LAI, SAMUEL
Format Patent
LanguageEnglish
French
Published 07.10.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described herein are binding proteins useful against ACE2-targeted viruses (e.g., SARS-CoV and SARS-CoV-2, etc.), and methods of using them. These binding proteins may include an extracellular portion of angiotensin-converting enzyme 2 (ACE2), excluding the collectrin domain, and a flexible polypeptide flexible linker coupling the ACE2 portion to a fragment crystallization (Fc) domain. These binding proteins dimerize, and the flexible linker may be chosen to be sufficiently long to permit concurrent interaction with multiple Spike (S) proteins on the ACE2-targeted virus. L'invention concerne des protéines de liaison utiles contre des virus ciblant ACE2 (par exemple, le SARS-CoV et le SARS-CoV-2, etc.), et leurs procédés d'utilisation. Ces protéines de liaison peuvent comprendre une partie extracellulaire de l'enzyme de conversion de l'angiotensine 2 (ACE2), à l'exclusion du domaine de collectrine, et un lieur flexible de polypeptide flexible couplant la partie ACE2 à un domaine de cristallisation de fragment (Fc). Ces protéines de liaison se dimérisent, et le lieur flexible peut être choisi pour être suffisamment long pour permettre une interaction concurrente avec de multiples protéines de spicule (S) sur le virus ciblant ACE2.
Bibliography:Application Number: CA20213173800