NANOFORMULATIONS OF METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE

The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of f...

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Main Authors CONTY, VALENTINA PAULA, FEY, PETER, HOHEISEL, WERNER, NEUMANN, HEIKE, OSTENDORF, MICHAEL, KERSTEN, ELISABETH, BECKER, GUIDO, SOWA, MICHAL, BROCKOB, JOERG, EHRIG, ANJA, LONGERICH, MARKUS
Format Patent
LanguageEnglish
French
Published 12.08.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions. La présente invention concerne des nanosuspensions stables de méthyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl))-1H-pyrazolo[3,4-b]pyridin-3-yl] pyrimidin-5-yl}carbamate (Vériciguat, composé de formule (I)), des procédés de préparation des nanosuspensions stables, des nanoparticules comprenant le composé de formule (I), et des compositions pharmaceutiques sous forme solide fabriquées à partir des nanosuspensions.
Bibliography:Application Number: CA20213169671