INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Methods of treating polyQ diseases or disorders such as Huntington's Disease are presented. Compounds of formula (I) of the disclosure are capable of binding directly to the polyQ segment of mutated huntingtin. This binding results in at least partial reversal of the conformation of mutated hun...

Full description

Saved in:
Bibliographic Details
Main Authors GALYAN, SIMON MARIUS, JUDD, DUNCAN BRUCE
Format Patent
LanguageEnglish
French
Published 02.09.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Methods of treating polyQ diseases or disorders such as Huntington's Disease are presented. Compounds of formula (I) of the disclosure are capable of binding directly to the polyQ segment of mutated huntingtin. This binding results in at least partial reversal of the conformation of mutated huntingtin to wild type huntingtin. The binding also facilitates autophagic removal of misfolded and/or mutated proteins such as mutated huntingtin. L'invention concerne des méthodes de traitement de maladies ou de troubles tels que la maladie de Huntington. Les composés de l'invention peuvent se lier directement au segment polyQ de la huntingtine mutée. Cette liaison entraîne une inversion au moins partielle de la conformation de la huntingtine mutée en huntingtine de type sauvage. La liaison permet également l'élimination autophagique des protéines mal repliées et/ou mutées telles que la huntingtine mutée.
Bibliography:Application Number: CA20213169300