HETEROCYCLIC PAD4 INHIBITORS

The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PA...

Full description

Saved in:
Bibliographic Details
Main Authors SISTLA, RAMESH KUMAR, TINO, JOSEPH A, SELVAKUMAR, KUMARAVEL, GORMISKY, PAUL E, ALAJANGI, TIRUPATHI RAO, MIAO, GUOBIN, DHAR, T. G. MURALI, MAHADEVU, KRISHNA, CHERNEY, ROBERT J, AGARWAL, PIYUSH, NAIR, JALATHI S, GARDNER, DANIEL S, DUNCIA, JOHN V, PAIDI, VENKATRAM REDDY, SUBBIAH KARUPPIAH, ARUL MOZHI, ROSS, AUDREY GRAHAM, ZHU, XIAO, CUERVO, JULIO HERNAN, KUMAR CM, VIJAYA, SELETSKY, BORIS M, MORAMPUDI, OOHA, PANDA, MANORANJAN, ANTROPOW, ALYSSA H, THANGATHIRUPATHY, SRINIVASAN, SURA, MALLIKARJUN REDDY, NIU, DEQIANG, ZHU, ZHENGDONG
Format Patent
LanguageEnglish
French
Published 19.08.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity. L'invention concerne globalement des composés hétérocycliques substitués de formule (Ia) qui sont des inhibiteurs de PAD4, une méthode de préparation de ces composés, des compositions pharmaceutiques comprenant ces composés et une utilisation de ces composés pour le traitement d'une maladie ou d'un trouble associé à l'activité enzymatique de PAD4.
Bibliography:Application Number: CA20213167753