SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS

• Main Authors: PULLIN, ROBERT, GALAN, BHAIRAVI, SCHMIDT, YVONNE, SHAW, DAVID MATTHEW, AHMAD, NADIA, HURLEY, DENNIS JAMES, DURRANT, STEVEN JOHN, NEUBERT, TIMOTHY DONALD, THOMSON, STEPHEN ANDREW, VIRANI, ANISA NIZARALI, PONTILLO, JOSEPH, CHUDYK, EWA IWONA, ETXEBARRIA JARDI, GORKA, HADIDA RUAH, SARA S, SKERRATT, SARAH, PINDER, JOANNE LOUISE, BECK, ELIZABETH MARY, KNEGTEL, RONALD MARCELLUS, STAMOS, DEAN, CARVALHO, MEIRLES LIDIO, WRAY, CHRISTOPHER
• Format: Patent
• Language: English; French
• Published: 10.06.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. L'invention concerne des composés, et des sels pharmaceutiquement acceptables de ceux-ci, utiles en tant qu'inhibiteurs de canaux sodiques. L'invention concerne également des compositions pharmaceutiques comprenant les composés ou des sels pharmaceutiquement acceptables et des procédés d'utilisation des composés, des sels pharmaceutiquement acceptables, et des compositions pharmaceutiques dans le traitement de divers troubles, y compris la douleur.