REACTIVE CONJUGATES

The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of a payload to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modif...

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Bibliographic Details
Main Authors SEGURA, JEAN-MANUEL, MARX, LEO, GARROUSTE, PATRICK, LEVY, FREDERIC, NYANGUILE, ORIGENE FRANZ, POSTUPALENKO, VIKTORIIA
Format Patent
LanguageEnglish
French
Published 10.06.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of a payload to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modified antibody fragment, which can be used for diagnosing, monitoring, imaging or treating disease. La présente invention concerne des composés (conjugués réactifs) pour la modification chimique d'anticorps ou de protéines thérapeutiques. Les composés permettent la fixation régiosélective d'une charge utile à un anticorps ou un fragment d'anticorps en une seule étape, ce qui permet de produire un anticorps modifié ou un fragment d'anticorps modifié, qui peut être utilisé pour diagnostiquer, surveiller, imager ou traiter une maladie.
Bibliography:Application Number: CA20203162958