JAK KINASE INHIBITOR PHARMACEUTICAL COMPOSITION

A JAK kinase inhibitor pharmaceutical composition, containing (3aR, 5s, 6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide or a pharmaceutically acceptable salt thereof and a composite auxiliary material, such as c...

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Bibliographic Details
Main Authors CHEN, HAO, JIANG, QIUDONG, XI, HONGLEI
Format Patent
LanguageEnglish
French
Published 01.07.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A JAK kinase inhibitor pharmaceutical composition, containing (3aR, 5s, 6aS)-N-(3-methoxy-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide or a pharmaceutically acceptable salt thereof and a composite auxiliary material, such as cellulose-lactose. The present invention has good stability, dissolution and bioavailability, and the preparation process thereof is simple and convenient. La présente invention concerne une composition pharmaceutique d'inhibiteur de JAK kinase, contenant du (3aR, 5s, 6aS)-N-(3-méthoxy-1,2,4-thiadiazol-5-yl)-5-(méthyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide ou son sel pharmaceutiquement acceptable et un matériau auxiliaire composite, tel que de la cellulose-lactose. La présente invention présente de bonnes qualités de stabilité, dissolution et biodisponibilité, et son procédé de préparation est simple et pratique.
Bibliography:Application Number: CA20203161463