COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and...

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Main Authors ESMIEU, WILLIAM RAMESHCHANDRA KRISHNA, ALROY, IRIS, HAMBLIN, JULIE NICOLE, SCHMIDT, WOLFGANG, MANSOUR, WISSAM, KLEPFISH, MOTY, BULL, RICHARD JAMES, MANDABI, AVIAD, SHEPPARD, DAVID WILLIAM, TIERNEY, JASON PAUL
Format Patent
LanguageEnglish
French
Published 05.08.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH). La présente invention concerne de nouveaux inhibiteurs de traduction du collagène 1, une composition, leurs procédés de préparation, et leurs utilisations pour le traitement de la fibrose notamment, le poumon, le foie, le rein, la fibrose cardiaque et dermique, l'IPF, la cicatrisation des plaies, la cicatrisation et la fibromatose gingivale, la sclérose systémique et la stéatohépatite alcoolique et non alcoolique (SHNA)
Bibliography:Application Number: CA20213161049