AMORPHOUS PHARMACEUTICAL COMPOSITIONS OF ABIRATERONE ACETATE

The present invention relates to a pharmaceutical composition comprising solid dispersion of amorphous abiraterone acetate and one or more pharmaceutically acceptable excipients, having improved solubility, stability, bioavailability, and no positive food effect. The present invention also relates t...

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Bibliographic Details
Main Authors DOGIPARTI, DHANUNJAY KUMAR, JASTI, VENKATESWARLU, NIROGI, RAMAKRISHNA, MUDIGONDA, KOTESHWARA, RAVULA, JYOTHSNA
Format Patent
LanguageEnglish
French
Published 11.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a pharmaceutical composition comprising solid dispersion of amorphous abiraterone acetate and one or more pharmaceutically acceptable excipients, having improved solubility, stability, bioavailability, and no positive food effect. The present invention also relates to a method for its preparation, a dosage form comprising such compositions, and the use of the said composition or dosage form as a medicament for the treatment of prostate cancer. La présente invention concerne une composition pharmaceutique comprenant une dispersion solide d'acétate d'abiratérone amorphe et un ou plusieurs excipients pharmaceutiquement acceptables, ayant une solubilité, une stabilité, une biodisponibilité améliorées et aucun effet alimentaire positif. La présente invention concerne également une méthode pour sa préparation, une forme posologique comprenant de telles compositions, et l'utilisation de ladite composition ou forme posologique en tant que médicament pour le traitement du cancer de la prostate.
Bibliography:Application Number: CA20203160834