THIENOPYRIMIDONES AS TRPA1 INHIBITORS

The present application relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions comprising the same and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related di...

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Main Authors WILLWACHER, JENS, BINDER, FLORIAN PAUL CHRISTIAN, HEHN, JOERG P, FLECK, MARTIN THOMAS, DAHMANN, GEORG, LESSEL, UTA FRIEDERIKE, HEIMANN, ANNEKATRIN CHARLOTTE
Format Patent
LanguageEnglish
French
Published 22.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present application relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions comprising the same and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases. La présente invention concerne des thiénopyrimidinones et leur utilisation en tant qu'inhibiteurs de l'activité de TRPA1, des compositions pharmaceutiques les comprenant et des procédés d'utilisation de celles-ci en tant qu'agents pour le traitement et/ou la prévention de maladies fibrotiques, de maladies inflammatoires et auto-immunes et de maladies associées au SNC.
Bibliography:Application Number: CA20203153115