ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN ROR1, AND USE FOR THE SAME
The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of...
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
11.03.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
La présente invention concerne de nouveaux conjugués anticorps-médicament (CAM) ciblant le ROR1, des métabolites actifs de tels CAM, des procédés de préparation de tels CAM, des utilisations de tels CAM dans le traitement et/ou la prévention de maladies, et des utilisations de tels CAM dans la production de médicaments pour le traitement et/ou la prévention de maladies, plus spécifiquement des maladies associées à une surexpression de ROR1, par exemple le cancer. Plus particulièrement, la présente invention concerne un conjugué anticorps-médicament comprenant un anticorps se liant au ROR1 ou un fragment de liaison d'antigène de celui-ci, et une composition pharmaceutique le comprenant. |
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Bibliography: | Application Number: CA20203153069 |