CR2 BINDING PROTEINS AND THEIR USE IN MEDICAL THERAPY

• Main Authors: ZHANG, JIAN, DIXON, DAVID, DIMECH, CAROLINE J, NISTALA, KIRAN, BAILEY, JAMES MATTHEW, MADURA, EMILIE, LEKOVA, ELEONORA, ELLSON, CHRISTIAN, DOS SANTOS CRUZ DE MANTOS, GABRIELA, HOOK, LAURA J, BOUMA, GERBEN, BURDEN, MICHAEL NEIL, KITCHEN, SEMRA
• Format: Patent
• Language: English; French
• Published: 04.03.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides CR2 binding proteins which bind to human CR2, pharmaceutical compositions comprising said CR2 binding proteins and their use in the treatment or prevention of autoimmune and/or inflammatory conditions, infectious diseases and malignancies associated with the Epstein-Barr virus (EBV); and their use as vaccine adjuvants/antigen carriers. La présente invention concerne des protéines de liaison CR2 qui se lient au CR2 humain, des compositions pharmaceutiques comprenant lesdites protéines de liaison CR2 et leur utilisation dans le traitement ou la prévention de maladies auto-immunes et/ou inflammatoires, de maladies infectieuses et de malignités associées au virus d'Epstein-Barr (EBV); et leur utilisation en tant qu'adjuvants de vaccins/porteurs d'antigènes.