HIGH YIELD YELLOW FEVER VIRUS STRAIN WITH INCREASED PROPAGATION IN CELLS

• Main Authors: GUERTIN, PATRICK M, LEE, CYNTHIA K, HAYMAN, EDWARD G, MONATH, THOMAS P
• Format: Patent
• Language: English; French
• Published: 12.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides a an inactive, non-replicating vaccine comprising whole virion,.chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection. Il est décrit un vaccin inactif et non réplicatif qui comprend un virion entier et le virus de la fièvre jaune inactivé par voie chimique dont linactivation est obtenue grâce à une méthode qui assure la préservation dépitopes neutralisants critiques. Le virus de la fièvre jaune est adapté pour se propager davantage dans les cellules que le virus non adapté. Il est également décrit des méthodes servant à prévenir linfection au virus de la fièvre jaune.