3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

• Main Authors: PARSONS, RACHEL JANE, MURRAY, JAMES BROOKE, DUNKEL, PETRA, RUDASOVA, MONIKA, MARAGNO, ANA LETICIA, NYERGES, MIKLOS, TIMARI, MATYAS PAL, NOVAK, TIBOR, HERNER, ANDRAS, MADARASZ, ZOLTAN, DODSWORTH, MARK PHILIP, SZIGETI, MARIANNA, WEBB, PAUL, COLLAND, FREDERIC, BEDFORD, SIMON, PACZAL, ATTILA, STROFEK, AGNES, CHANRION, MAIA, DAVIDSON, JAMES EDWARD PAUL, MOLNAR, MARK, STARCK, JEROME-BENOIT, DESOS, PATRICE, KOTSCHY, ANDRAS
• Format: Patent
• Language: English; French
• Published: 04.02.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

It is described a compounds of formula (I): a pharmaceutical composition comprising same, for use in the treatment of cancers, of diseases or conditions characterized by an excess or a deregulated activity of platelets. Also provided is the synthesis of intermediate Il est décrit des composés de formule (I) : une composition pharmaceutique connexe à utiliser dans le traitement de cancers, de maladies ou de problèmes caractérisés par un excédent, ou une activité sans régulation, de plaquettes. Il est également décrit la synthèse d'intermédiaires.