SOLID FORMS OF AN HPK1 INHIBITOR

The present invention relates to salt forms of the hematopoietic progenitor kinase 1 (HPK1) inhibitors N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-5-fluorophenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyanopy...

Full description

Saved in:
Bibliographic Details
Main Authors FRIETZE, WILLIAM, JIA, ZHONGJIANG
Format Patent
LanguageEnglish
French
Published 11.02.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to salt forms of the hematopoietic progenitor kinase 1 (HPK1) inhibitors N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-5-fluorophenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyanopyridin-3-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide, including methods of preparation thereof, where the compounds are useful in the treatment of HPK1 mediated diseases such as cancer. La présente invention concerne des formes salines d'inhibiteurs de la kinase 1 progénitrice hématopoïétique (HPK1) N-(2-((2S,4S)-4-Amino-2-(hydroxyméthyl)pyrrolidin-1-yl)-5-fluorophényl)-2-(2-fluoro-6-méthoxyphényl)pyrimidine-4-carboxamide et N-(2-((2S,4S)-4-Amino-2-(hydroxyméthyl)pyrrolidin-1-yl)-4-(4-cyanopyridin-3-yl)phényl)-2-(2-fluoro-6-méthoxyphényl)pyrimidine-4-carboxamide, y compris des procédés de préparation associés, les composés étant utiles dans le traitement de maladies médiées par HPK1 telles que le cancer.
Bibliography:Application Number: CA20203147918