SMALL MOLECULE LIVER X RECEPTOR MODULATORS AND USES THEREOF

• Main Authors: GILBERTSON, SCOTT, LIN, CHIN-YO
• Format: Patent
• Language: English; French
• Published: 11.03.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Small molecule liver X receptor (LXR) modulators, and derivatives thereof, exhibit activity against tumor cells and less or no activity against dividing non-malignant cells, target the liver X receptor and disrupt key metabolic pathways preferred by cancer cells, and activate a newly discovered cell...