METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

The present invention relates to a crystalline polymorph I of (4S)- 4-(4-cyano- 2-methoxypheny1)-5- ethoxy-2,8-dimethyl- 1,4-dihydro- 1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of thereof for treatment of a cardiovascular disorder. La présente invention conce...

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Bibliographic Details
Main Authors GRUNENBERG, ALFONS, GARKE, GUNNAR, PLATZEK, JOHANNES
Format Patent
LanguageEnglish
French
Published 02.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a crystalline polymorph I of (4S)- 4-(4-cyano- 2-methoxypheny1)-5- ethoxy-2,8-dimethyl- 1,4-dihydro- 1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of thereof for treatment of a cardiovascular disorder. La présente invention concerne un polymorphe cristallin I de (4S) - 4- (4-cyano- 2-méthoxyphény1) -5- éthoxy-2,8-diméthyl- 1,4-dihydro- 1,6-naphtyridine-3-carboxamide de formule (I) , ainsi que la préparation et l'utilisation de celui-ci pour le traitement d'un trouble cardiovasculaire.
Bibliography:Application Number: CA20153146285