ADRENOMEDULLIN-ANALOGUES FOR LONG-TERM STABILIZATION AND THEIR USE

• Main Authors: FLAMME, INGO, HOFMEISTER, LUCAS HUDSON, FISCHER, JAN-PATRICK, BIERER, DONALD, ELS-HEINDL, SYLVIA, JULKE, EVA-MARIA, KOBBERLING, JOHANNES, RIEDL, BERND, BECK-SICKINGER, ANNETTE
• Format: Patent
• Language: English; French
• Published: 24.12.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to stabilized Adrenomedullin derivatives and use thereof. In particular, the invention relates to novel, biologically active, stabilized Adrenomedullin (ADM) compounds. The invention further relates to the compounds for use in a method for the treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, and to medicaments comprising the compounds for treatment and/or prevention of cardiovascular, edematous and/or inflammatory disorders. L'invention concerne des dérivés d'adrénomédulline stabilisés et leur utilisation. En particulier, l'invention concerne de nouveaux composés d'adrénomédulline (ADM) biologiquement actifs et stabilisés. L'invention concerne en outre les composés destinés à être utilisés dans un procédé de traitement et/ou de prévention de maladies, en particulier de troubles cardiovasculaires, oedémateux et/ou inflammatoires, et des médicaments comprenant les composés pour le traitement et/ou la prévention de troubles cardiovasculaires, oedémateux et/ou inflammatoires.