SUSTAINED-RELEASE COMPOSITIONS OF ALPHA-KETOGLUTARATE

Controlled-release formulations of calcium alpha-ketoglutarate (Ca-AKG) are described. The formulations comprise HPMC and provide sustained and consistent release of Ca-AKG. Such formulations encompass a composition comprising (a) Ca-AKG, and (b) a controlled-release matrix comprising hydroxypropylm...

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Bibliographic Details
Main Authors PEREIRA, DAVID EUGENE, KONAR, SUMANA
Format Patent
LanguageEnglish
French
Published 17.12.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Controlled-release formulations of calcium alpha-ketoglutarate (Ca-AKG) are described. The formulations comprise HPMC and provide sustained and consistent release of Ca-AKG. Such formulations encompass a composition comprising (a) Ca-AKG, and (b) a controlled-release matrix comprising hydroxypropylmethylcellulose (HPMC) with number average molecular weight of about 68,000 to about 95,000, or with number average molecular weight of about 115,000 to about 150,000, or a combination thereof. Il est décrit des formulations à libération régulée de calcium alpha-cétoglutarate (Ca-AKG). Les formulations comprennent de l'hydroxypropyleméthyl cellulose (HPMC) et fournissent une libération continue et consistante de Ca-AKG. De telles formulations englobent une composition comprenant (a) Ca-AKG et (b) une matrice de libération contrôlée comprenant de l'hydroxypropyleméthyl cellulose (HPMC) avec un poids moléculaire moyen en nombre d'environ 68 000 à environ 95 000, ou avec un poids moléculaire moyen en nombre d'environ 115 000 à environ 150 000, ou une combinaison de ceux-ci.
Bibliography:Application Number: CA20203142494