SOLID FORMS OF {6-[(2-AMINO-3-CHLOROPYRIDIN-4-YL)SULFANYL]-3-[(3S,4S)-4-AMINO-3-METHYL-2-OXA-8-AZASPIRO[4.5]DECAN-8-YL]-5-METHYLPYRAZIN-2-YL}METHANOL, AN SHP2 INHIBITOR

The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4- yl)sulfanyl]-3-[(3,S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]- 5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutica...

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Bibliographic Details
Main Authors LI, SHAOLING, BALLMER, STEVEN G
Format Patent
LanguageEnglish
French
Published 10.12.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4- yl)sulfanyl]-3-[(3,S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]- 5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. La présente invention concerne des formes solides cristallines de {6-[(2-amino-3-chloropyridin-4- yl)sulfanyl]-3-[(3,S,4S)-4-amino-3-méthyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-méthylpyrazin-2-yl}méthanol, ou un sel pharmaceutiquement pharmaceutically de celles-ci, le procédé de préparation de ces formes, et des compositions pharmaceutiques et des procédés d'utilisation de celles-ci.
Bibliography:Application Number: CA20203142430