COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PD-L1 INHIBITORS

Therapeutic combinations of hepatitis B virus (HBV) vaccines and PD-L1 inhibitors are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations of HBV vaccin...

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Main Authors VAN BRANDT, SVEN FRANCISCUS ANNA, MC GOWAN, DAVID CRAIG, HORTON, HELEN, VAN GULCK, ELLEN ROSALIE A, VAN DONGEN, MARIA JOHANNA PETRONELLA
Format Patent
LanguageEnglish
French
Published 24.12.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Therapeutic combinations of hepatitis B virus (HBV) vaccines and PD-L1 inhibitors are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations of HBV vaccines and PD-L1 inhibitors are also described. Kits comprising the disclosed therapeutic combinations are also described. L'invention concerne des associations thérapeutiques de vaccins contre le virus de l'hépatite B (HBV) et d'inhibiteurs de PD-L1. L'invention concerne également des procédés d'induction d'une réponse immunitaire contre le VHB ou de traitement d'une maladie induite par le VHB, en particulier chez des individus présentant une infection chronique par le VHB, à l'aide desdites associations thérapeutiques de vaccins contre le VHB et d'inhibiteurs de PD-L1. L'invention concerne également des kits comprenant les associations thérapeutiques décrites.
Bibliography:Application Number: CA20203141003