COMPOSITION AND METHODS FOR RECTAL DELIVERY OF 4-AAPA AND 5-ASA COMPOUNDS

The invention, in various aspects and embodiments, provides compositions and methods for treating or preventing inflammation of the lower gastrointestinal tract. The compositions and methods in various embodiments relate to rectal administration of pharmaceutical compositions that comprise an agent...

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Bibliographic Details
Main Authors RADHAKRISHNAN, BALASINGHAM, APPAJOSYULA, SIREESH, MADAN, JAY, LAUMAS, SANDEEP
Format Patent
LanguageEnglish
French
Published 15.10.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention, in various aspects and embodiments, provides compositions and methods for treating or preventing inflammation of the lower gastrointestinal tract. The compositions and methods in various embodiments relate to rectal administration of pharmaceutical compositions that comprise an agent that forms one or more 4-AAPA compounds or 5 -ASA compounds by azo reduction. In various embodiments, the compositions and methods treat, reduce, or prevent inflammation of the colon and/or rectum, as well as in some embodiments, an ileo-anal pouch in a subject. Compositions for rectal administration can be formulated as emulsions, suppositories (both suspension and solid), gels, and foam and foamable pharmaceutical compositions. L'invention, dans divers aspects et modes de réalisation, concerne des compositions et des méthodes pour traiter ou prévenir l'inflammation du tractus gastro-intestinal inférieur. Les compositions et les méthodes dans divers modes de réalisation concernent l'administration rectale de compositions pharmaceutiques qui comprennent un agent qui forme un ou plusieurs composés 4-AAPA ou composés 5-ASA par réduction azoïque. Dans divers modes de réalisation, les compositions et les méthodes permettent de traiter, diminuer ou prévenir chez le patient l'inflammation au niveau du côlon et/ou du rectum, ainsi que dans certains modes de réalisation, au niveau d'une poche iléo-anale. Les compositions pour administration rectale peuvent être formulées sous la forme d'émulsions, de suppositoires (aussi bien de type suspension que solide), de gels, et de mousses et de compositions pharmaceutiques moussables.
Bibliography:Application Number: CA20203136718