INTEGRATED AND CONTINUOUS RECOMBINANT PROTEIN MANUFACTURING

Integrated systems and methods for the manufacturing of recombinant proteins in mammalian cells are provided. The systems and methods include a single-use bioreactor (SUB), a tangential flow filtration system, a column chromatography skid, a tankless hold, a virus inactivation plug flow reactor, and...

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Main Authors FIADEIRO, MARCUS ANDRE, MCLAUGHLIN, JOSEPH K, COFFMAN, JONATHAN, GODFREY, SCOTT A, KOTTMEIER, ROBERT E, FAHRNER, ROBERT LEE, OROZCO, RAQUEL, SALM, JEFFREY RICHARD
Format Patent
LanguageEnglish
French
Published 08.10.2020
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:Integrated systems and methods for the manufacturing of recombinant proteins in mammalian cells are provided. The systems and methods include a single-use bioreactor (SUB), a tangential flow filtration system, a column chromatography skid, a tankless hold, a virus inactivation plug flow reactor, and pumps. L'invention concerne également des systèmes et des procédés intégrés pour la fabrication de protéines recombinées dans des cellules de mammifère. Les systèmes et les procédés comprennent un bioréacteur à usage unique (SUB), un système de filtration à flux tangentiel, un patin de chromatographie en colonne, un dispositif de maintien sans réservoir, un réacteur d'écoulement à bouchon d'inactivation de virus et des pompes.
Bibliography:Application Number: CA20203131430