UNIVERSAL DONOR STEM CELLS AND RELATED METHODS

Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed he...

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Bibliographic Details
Main Authors COWAN, CHAD A, FERREIRA, LEONARDO M. R, STROMINGER, JACK L, MEISSNER, TORSTEN B
Format Patent
LanguageEnglish
French
Published 20.08.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein have modulated expression of one or more MHC-I and MHC-II human leukocyte antigens and one or more tolerogenic factors. L'invention concerne des cellules souches donnatrices universelles et leurs méthodes associées d'utilisation et de production. Les cellules souches donnatrices universelles selon l'invention sont utiles pour surmonter le rejet immunitaire dans des thérapies de transplantation à base de cellules. Selon certains modes de réalisation, les cellules souches donnatrices universelles révélées ici ont une expression modulée d'un ou de plusieurs antigènes leucocytaires humains MHC-I et MHC-II et d'un ou de plusieurs facteurs tolérogéniques.
Bibliography:Application Number: CA20203130398