CONSTITUTIVELY ACTIVE CHIMERIC CYTOKINE RECEPTORS

Provided herein are constitutively active chimeric cytokine receptors (CACCRs). When present on chimeric antigen receptor (CAR)-bearing immune cells, such CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Also provided are methods of making and using the...

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Bibliographic Details
Main Authors VAN BLARCOM, THOMAS JOHN, LIN, REGINA JUNHUI, PANOWSKI, SILER, SASU, BARBRA JOHNSON
Format Patent
LanguageEnglish
French
Published 10.09.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided herein are constitutively active chimeric cytokine receptors (CACCRs). When present on chimeric antigen receptor (CAR)-bearing immune cells, such CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Also provided are methods of making and using the CACCRs described herein. La présente invention concerne des récepteurs de cytokine chimériques constitutivement actifs. De telles cellules immunitaires permettent d'augmenter, lorsqu'elles sont présentes sur des cellules immunitaires portant des récepteurs antigéniques chimériques (CAR), l'activation, la prolifération, la persistance et/ou la puissance des cellules immunitaires. L'invention concerne également des procédés de fabrication et d'utilisation de CACCR selon l'invention.
Bibliography:Application Number: CA20203129865