IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY TO THE LUNG

There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides an...

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Main Authors SALLETS, ADRIENNE, BLAKE, TIM R, WAYMOUTH, ROBERT M, WENDER, PAUL, HAABETH, OLE AUDUN WERNER, MCCLELLAN, REBECCA, LEVY, RONALD
Format Patent
LanguageEnglish
French
Published 06.08.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into lung cells and lung tissue, both in vitro and in vivo. L'invention concerne, entre autres, des complexes, des compositions et des procédés pour l'administration d'agents thérapeutiques, de diagnostiques et d'imagerie, notamment un acide nucléique, dans une cellule. Les complexes, compositions et procédés peuvent permettre la complexation, la protection, l'administration et la libération d'oligonucléotides et de protéines cargo polyanioniques dans les cellules et les tissus pulmonaires à la fois in vitro et in vivo.
Bibliography:Application Number: CA20203128476