METHODS OF TREATING MULTIPLE MYELOMA

The present disclosure provides methods for treating multiple myeloma (such as refractory multiple myeloma or relapsed and refractory multiple myeloma) in an individual who received at least two prior therapies for multiple myeloma. The methods comprise administering to the individual an anti-CD38 a...

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Bibliographic Details
Main Authors AUDAT, HELOISE, CAMPANA ZAMBRANO, FRANK, LE-GUENNEC, SOLENN, BONESTEBE, AUDREY, MANACHE-ALBERICI, LUCIE, HUILLE, SYLVAIN
Format Patent
LanguageEnglish
French
Published 06.08.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides methods for treating multiple myeloma (such as refractory multiple myeloma or relapsed and refractory multiple myeloma) in an individual who received at least two prior therapies for multiple myeloma. The methods comprise administering to the individual an anti-CD38 antibody, pomalidomide, and dexamethasone. Also provided are methods of improving renal impairment in an individual having multiple myeloma. La présente invention concerne des méthodes de traitement du myélome multiple (tels que le myélome multiple réfractaire ou le myélome multiple avec rechute et réfractaire) chez un individu qui a reçu au moins deux thérapies antérieures pour le myélome multiple. Les méthodes selon l'invention comprennent l'administration à l'individu d'un anticorps anti-CD38, du pomalidomide et de la dexaméthasone. L'invention concerne également des méthodes permettant d'atténuer l'insuffisance rénale chez un individu présentant un myélome multiple.
Bibliography:Application Number: CA20203127928