SYSTEMS AND METHODS FOR MODULATING CRISPR ACTIVITY

Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides. L'invention concerne des polyn...

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Bibliographic Details
Main Authors CARLSON-STEVERMER, JARED, WALKER, JOHN ANDREW, JOSHI, SAHIL, KELSO, REED, MAURES, TRAVIS, KADINA, ANASTASIA
Format Patent
LanguageEnglish
French
Published 30.07.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides. L'invention concerne des polynucléotides comprenant une séquence conçue pour se lier à une protéine effectrice CRISPR. La modulation d'une ou plusieurs modifications des polynucléotides peut être utilisée pour accorder l'activité de protéines effectrices CRISPR complexées avec les polynucléotides.
Bibliography:Application Number: CA20203127486