GALECTIN-7-SPECIFIC MONOVALENT ANTIBODIES AND USES THEREOF

• Main Authors: ST-PIERRE, YVES, DOUCET, NICOLAS, CHATENET, DAVID
• Format: Patent
• Language: English; French
• Published: 16.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Monovalent antibodies such as nanobodies that are specific for galectin-7 are described. These monovalent antibodies are able to interfere with the dimerization of galectin-7, and thus may be used for the treatment of diseases associated with dysregulated galectin-7 expression and/or activity, such as certain types of cancers as well as eye diseases or conditions associated with pathological neovascularization or angiogenesis. L'invention concerne des anticorps monovalents tels que des nanocorps qui sont spécifiques de la galectine-7. Ces anticorps monovalents peuvent interférer avec la dimérisation de la galectine-7, et peuvent ainsi être utilisés pour le traitement de maladies associées à l'expression et/ou à l'activité de la galectine-7 dérégulée, tels que certains types de cancers ainsi que des maladies ou affections oculaires associées à une néovascularisation pathologique ou à une angiogenèse pathologique.