PROCESS FOR PREPARING 1-[(3R,4S)-4-CYANOTETRAHYDROPYRAN-3-YL]-3-[(2-FLUORO-6-METHOXY-4-PYRIDYL)AMINO]P YRAZOLE-4-CARBOXAMIDE
The application relates to processes for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can...
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Main Authors | , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
18.06.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The application relates to processes for the preparation of 1-[(3R,4S) -4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).
L'invention concerne des procédés de préparation de 1- [(3R,4S)-4-cyanotétrahydropyran-3-yl]-3-[(2-fluoro-6-méthoxy-4-pyridyl)amino]pyrazole-4-carboxamide (I) qui comprennent (i) une synthèse d'intermédiaires de type bromopyridine et iodopyridine, (ii) une synthèse d'un intermédiaire de type ester de pyrazole qui peut être obtenu sous une forme énantiomère pure et (iii) la combinaison de ces intermédiaires en composé (I). |
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Bibliography: | Application Number: CA20193122183 |