C11-CYCLIC SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF

Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13- membered macrolides, and methods of treating...

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Main Authors CARLSEN, PETER NIELS, LAWRENCE, JONATHAN F, GONDI, VIJAYA, ALM, RICHARD, RAHMAN, MD. ATAUR, ZHANG, ZIYANG, AUSTIN, WESLEY FRANCIS, SHI, SHUHAO, LAHIRI, SUSHMITA D, HOGAN, PHILIP, ICHIKAWA, YOSHITAKA, MYERS, ANDREW G, LI, XIBEN, CLARK, ROGER B, WANG, WENYING, JEWETT, IVAN
Format Patent
LanguageEnglish
French
Published 28.05.2020
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13- membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides. L'invention concerne des macrolides à 13 chaînons pour le traitement de maladies infectieuses. Les macrolides à 13 chaînons selon l'invention sont des azacétolides. L'invention concerne également des procédés de préparation des macrolides à 13 chaînons, des compositions pharmaceutiques comprenant les macrolides à 13 chaînons et des méthodes de traitement de maladies infectieuses et, en particulier, d'une maladie provoquée par des bactéries à Gram négatif, à l'aide des macrolides selon l'invention.
Bibliography:Application Number: CA20193120235