FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neur...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
30.04.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
L'invention concerne un composé de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, qui sont de puissants modulateurs de l'activité du TNF a humain, et trouvent ainsi une utilité dans le traitement et/ou la prévention de diverses affections humaines, notamment des troubles auto-immuns et inflammatoires ; des troubles neurologiques et neurodégénératifs ; la douleur et des troubles nociceptifs ; des troubles cardiovasculaires ; des troubles métaboliques ; des troubles oculaires ; et des troubles oncologiques. |
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| AbstractList | A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
L'invention concerne un composé de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, qui sont de puissants modulateurs de l'activité du TNF a humain, et trouvent ainsi une utilité dans le traitement et/ou la prévention de diverses affections humaines, notamment des troubles auto-immuns et inflammatoires ; des troubles neurologiques et neurodégénératifs ; la douleur et des troubles nociceptifs ; des troubles cardiovasculaires ; des troubles métaboliques ; des troubles oculaires ; et des troubles oncologiques. |
| Author | XUAN, MENGYANG JOHNSON, JAMES ANDREW GALLIMORE, ELLEN OLIVIA |
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| DocumentTitleAlternate | DERIVES D'IMIDAZOLE PENTACYCLIQUES FUSIONNES UTILISES EN TANT QUE MODULATEURS DE L'ACTIVITE DU TNF |
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| Snippet | A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of... |
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| Title | FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
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