FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neur...

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Bibliographic Details
Main Authors GALLIMORE, ELLEN OLIVIA, XUAN, MENGYANG, JOHNSON, JAMES ANDREW
Format Patent
LanguageEnglish
French
Published 30.04.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNF a activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. L'invention concerne un composé de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, qui sont de puissants modulateurs de l'activité du TNF a humain, et trouvent ainsi une utilité dans le traitement et/ou la prévention de diverses affections humaines, notamment des troubles auto-immuns et inflammatoires ; des troubles neurologiques et neurodégénératifs ; la douleur et des troubles nociceptifs ; des troubles cardiovasculaires ; des troubles métaboliques ; des troubles oculaires ; et des troubles oncologiques.
Bibliography:Application Number: CA20193117344